Department Chair, Dominick P. Purpura Department of Neuroscience
Behavioral/Cellular Molecular/Clinical
Cerebellar physiology and function; Motor coordination and movement disorders; Cerebellar contribution to non-motor functions, Autism, schizophrenia, addiction and migraine; Neuronal Excitability and Synaptic transmission
Professor, Dominick P. Purpura Department of Neuroscience
Harold and Muriel Block Chair in Neuroscience
(neuroscience category)
Excitatory and inhibitory synaptic transmission and plasticity under physiological and brain disease conditions, such as Alzheimer’s disease, epilepsy, autism, schizophrenia and drug abuse
Associate Professor, Dominick P. Purpura Department of Neuroscience
(neuroscience category)
Functions of metabotropic glutamatergic signaling in neuronal plasticity and homeostasis; impact of mGluR-interacting proteins and lipids on synaptic functions in animal models of Fragile X syndrome, intellectual disability and schizophrenia
Professor, Dominick P. Purpura Department of Neuroscience
(neuroscience category)
Connectomics, ciliogenesis, genetic control of axon guidance, axonal transport, and neuronal cell fate in Caenorhabditis elegans, tubulogenesis in nematode epithelia, anatomy of aging in nematode tissues, new methods in EM
Associate Professor, Dominick P. Purpura Department of Neuroscience
Associate Professor, Psychiatry and Behavioral Sciences
(neuroscience category)
Synaptic plasticity; RNA transport and local translation; synapse-to-nucleus signaling; Proteomic analysis of the dynamics of synaptic junctions; molecular mechanisms underlying neurodevelopmental disorders.
Professor, Dominick P. Purpura Department of Neuroscience
Professor, Department of Ophthalmology and Visual Sciences
Professor, Departmen of Systems and Computational Biology
Isidor Tachna Professor in Ophthalmology
(neuroscience category)
My lab studies visual processing, with a focus on issues of rapid cortical plasticity, population coding, and inter-areal communication. We use neurophysiological, computational and behavioral methods in our work.
Professor, Dominick P. Purpura Department of Neuroscience
(neuroscience category)
We investigate how the brain selects relevant features of the environment to encode information efficiently. We study hearing in birds, using their specialized behaviors to elucidate fundamental principles of brain function.
Professor, Dominick P. Purpura Department of Neuroscience
(neuroscience category)
Synaptic transmission; properties and plasticity of gap junction-mediated electrical synapses; functional interactions between chemical and electrical synapses.
Assistant Professor, Dominick P. Purpura Department of Neuroscience
Co-primary, Assistant Professor, Department of Psychiatry and Behavioral Sciences
(neuroscience category)
Our research focuses on how neuromodulation affects synaptic plasticity, inhibition, and multisensory integration to shape behavior in health and disease.
Assistant Professor, Dominick P. Purpura Department of Neuroscience
(neuroscience category)
We study decision-making and drug addiction in rodent models using a broad approach that incorporates cutting edge methods from both systems and molecular neuroscience.
Professor, Dominick P. Purpura Department of Neuroscience
Professor, Otorhinolaryngology—Head and Neck Surgery
(neuroscience category)
Neurobiology of auditory perception, attention, and memory; human electrophysiology; neural adaptation; multisensory interactions in perception; changes in auditory cognition across the lifespan; neurodevelopmental disorders
Professor, Dominick P. Purpura Department of Neuroscience
(neuroscience category)
Sensorineural syndromic deafness; biophysical characterization of mutant connexin 26 channels; generation of mouse models that capitalize on aberrant channel functions; development of pharmacological agents for treatment
Professor, Dominick P. Purpura Department of Neuroscience
F.M. Kirby Chair of Neural Repair and Protection
Director, Neuropsychopharmacology Center
(neuroscience category)
Regulation of synaptic function and plasticity in response to external cues including neuronal insults, maternal deprivation, and stress, via epigenetic mechanisms. Altered signaling at the synapse in mouse models of autism.